About Edgewise Therapeutics
At Edgewise, we are on a mission to discover new medicines that improve the lives of patients facing serious muscle disease. Our intimate knowledge of muscle biology and biophysics along with our ability to identify and design muscle specific precision small molecules have enabled us to rapidly advance our skeletal muscle and cardiac muscle product candidates into the clinic while also building a robust pre-clinical pipeline. With this focus on therapeutics designed to protect and improve muscle health, our goal is to dramatically enhance the lives of people living with progressive muscle disorders.
We have assembled an experienced and highly motivated leadership team with a strong track record in the biotechnology and pharmaceutical industry to build the leading, global muscle disease biopharmaceutical company. Come join us make a significant difference in the lives of patients!
Position Summary:
Reporting to Chief Development Officer, the VP of Cardiovascular Clinical Development will be a key member of the R&D leadership team, responsible for overseeing clinical development of the cardiovascular portfolio. This leader will be viewed as a strategic partner to the CDO, helping to determine the strategy and standards of operational excellence and implementation across clinical development.
Key Responsibilities:
- Lead and oversee cardiovascular clinical development strategy forward with an eye towards operational excellence in execution and innovation.
- Serve as principal medical expert on Phase 1 and Phase 2 studies and mapping out the clinical development plan.
- Act as a sponsor medical monitor, testing the clinical hypotheses and early proof of concept of assets.
- Assist the CV translational research and discovery Team with identifying appropriate clinical populations for pipeline assets and the design of translational studies to refine proof of concept hypotheses..
- Support the development of regulatory strategies for cardiovascular development programs. Identify and communicate potential risks.
- Develop strategies for complex issues with potential for significant regulatory compliance impact. Ensure continued regulatory compliance of products.
- Collaborate with the Business Development function to help refine strategy and evaluate opportunities as they arise.
- Represent the Company in various external forums as needed, increasing the profile of the Company through outstanding communication skills.
- Read, understand, and comply with all workplace health and safety policies; safe work practices; and company policies and procedures.
- Perform other duties as assigned by supervisor.
Education, Experience, Skills:
The successful candidate will combine their expertise in cardiovascular clinical development with an innovative mindset to help the Company accelerate and expand their pipeline.
In terms of the performance and personal competencies required for the position, we would highlight:
- MD with minimum 10+ years of experience in CV/HF clinical investigation & development with a deep understanding of cardiac physiology and pharmacology. Experience in genetic cardiomyopathies preferred.
- Demonstrates an exceptional track record of accomplishment in CV clinical development, consistently transforming science into development-stage programs and marketed medicines.
- Experience leading a portfolio of programs at different clinical stages and has demonstrated the ability to collaborate with both commercial and research.
- Demonstrated ability in building and scaling a clinical development team and organization.
- Develops strong cross-functional working relationships with a diverse team of senior leaders.
- Experience in successfully managing the interfaces with discovery, translational, early/late-stage development, regulatory, safety and clinical operations organizations.
- Brings a global perspective with experience in regulatory filings in US and EU.
- Closely connected with key stakeholders globally (regulators, KOLs, universities, VCs, biotechnology companies, clinical community, patient groups, policymakers).
- Makes smart decisions, places strategic bets, makes tough portfolio and resource allocation decisions, to maximize return on investment.
- Builds a high level of trust and partnership with the Executive Leadership Team.
- Has the gravitas, confidence, and executive presence to operate with business leaders. Self-confident, but without ego.
- Brings strong scientific credibility, coupled with business acumen, and the ability to roll up sleeves and dig into the details.
- Experience interfacing with regulatory agencies, thorough knowledge and understanding of regulatory requirements for pharmaceutical/biological product development and approval in more than one key region (i.e. US, Europe).
In terms of the performance and personal competencies required for the position, we would highlight the following:
Setting Strategy
- The ability to create and articulate an inspiring vision for the organization, not only for the areas s/he is directly responsible for, but the enterprise.
- The inclination to seek and analyze data from a variety of sources to support decisions and to align others with the organization's overall strategy.
- An entrepreneurial and creative approach to developing new, innovative ideas that will stretch the organization and push the boundaries within the industry.
- The ability to effectively balance the desire/need for broad change with an understanding of how much change the organization is capable of handling, to create realistic goals and implementation plans that are achievable and successful.
Executing for Results
- The ability to set clear and challenging goals while committing the organization to improved performance; tenacious and accountable in driving results.
- Comfortable with ambiguity and uncertainty; the ability to adapt nimbly and lead others through complex situations.
- A risk-taker who seeks data and input from others to foresee possible threats or unintended circumstances from decisions; someone who takes smart risks.
- A leader who is viewed by others as having a high degree of integrity and forethought in his/her approach to making decisions; the ability to act in a transparent and consistent manner while always taking into account what is best for the organization.
Leading Teams
- The ability to attract and recruit top talent, motivate the team, delegate effectively, celebrate diversity within the team, and manage performance; widely viewed as a strong developer of others.
- The ability to persevere in the face of challenges and exhibit a steadfast resolve and relentless commitment to higher standards, which commands respect from followers.
- A leader who is self-reflective and aware of his/her own limitations; leads by example and drives the organization's performance with an attitude of continuous improvement by being open to feedback and self-improvement.
Relationships and Influence
- Naturally connects and builds strong relationships with others, demonstrating strong emotional intelligence and an ability to communicate clearly and persuasively.
- An ability to inspire trust and followership in others through compelling influence, powerful charisma, passion in his/her beliefs, and active drive.
- Encourages others to share the spotlight and visibly celebrates and supports the success of the team.
- Creates a sense of purpose/meaning for the team that generates followership beyond his/her own personality and engages others to the greater purpose for the organization as a whole.
Salary range: $300,000-400,000, title and salary commensurate with experience
Our Benefits: We are proud to offer health benefits, a discretionary bonus plan, stock option grants. a stock purchase plan, a 401(k) with match and paid time off to our team members as part of their compensation plan.
There is no deadline because the employer accepts applications on an ongoing basis.
Edgewise does not accept resumes from recruitment agencies for this position. Please do not send resumes to Edgewise employees or the company location. Edgewise is not responsible for any fees related to unsolicited resumes.
